@Emotal Lack of motivation and energy are major symptoms. It is similar to when your physically sick and your body has to put so much energy into fighting your disease that it zaps your energy. When your depressed, the brain is taking so much energy to feel normal. Therefore you get these symptoms. I will give a disclaimer, if he does not get treatment this will not easily change. So if he is treatment resistant, ask yourself what you will tolerate. Irritability and coldness should not cross the line into disrespect or cruel treatment.